Edmund McMillen and Tyler Glaiel, the creators of popular indie games, have delivered another fantastic experience with Mewgenics. This roguelike features a wide range of enemies, and players will want to be prepared for every challenge. This guide covers all the bosses in Mewgenics, including hidden bosses, invaders, and enemies that only appear during specific events.
Mewgenics Boss Guide
Mewgenics organizes its bosses into distinct categories. You’ll encounter five main types of these enemies throughout the game.
- General Threats: Every act has a number of creatures, like Kitten, Flies, Cat Caller, etc., which you must fight at different stages to progress further.
- Mini-Bosses: These are slightly harder encounters, normally around four in the first zone, with fewer appearing as you advance to new arenas.
- Final Bosses: Every chapter in Mewgenics has a couple of final bosses (usually one), so you can meet around seven to eight of them throughout an entire act.
- House Bosses: These invade your home on their own after you clear certain areas.
- Special Bosses: Some events along the way allow you to fight these rare mobs.
All Act 1 Bosses in Mewgenics
Image Credits: Edmund McMillen, Tyler Gladiel
| Chapter | Mini Boss | Final Boss |
|---|---|---|
| The Alley | Lucy Magnus Fenrir Maisie Arthur (Special) | Radical Rat (Easy Path) Queen Hippo (Hard Path) |
| The Sewers | The Flushmaster Rat King | Boris |
| The Junkyard | Can Creeper Trampy | Chubs & Nubs |
| The Caves | Big Slime | One Baby Spider |
| The Boneyard | Mama Maggot | Dybbuk |
| The Throbbing Domain (Secret) | None | Throbbing King |
Others from Act 1
| House Boss | Location |
|---|---|
| Guillotina | This giant cat will show up at your hut to eat your cats seven days after you finish Chapter Three, including both The Caves and The Boneyard. |
| Guillotina 2 | She’s basically Guillotina in a different form, and she pops up seven mornings after you kill the home boss. |
| Guillotina 3 | This most terrifying version of Guillotina raids your property several days later, following the defeat of her earlier form. |
All Act 2 Bosses in Mewgenics
Image via Edmund McMillen, Tyler Glaiel | Chapter | Mini Boss | Final Boss |
|---|---|---|
| The Desert | Dack Gein Morana Marshmallow Arthur (Special) Dust Devil (Special) | Gambit (Easy Path) Zodiac (Hard Path) |
| The Crater | Infested Pair Rocky Bobo | Crater Maker |
| The Bunker | Bumblefoot Lenny | Johnny |
| The Moon | The Abandoned Ones | The Man in the Moon |
| The Core | Cerberubs | The Coven |
| The Rift (Secret) | None | Chaos Soahc |
Others from Act 2
| House Boss | Location |
|---|---|
| Pyrophina | Since she’s also a House Boss like Guillotina, you’ll be able to deal with her from your place seven days after crushing The Core. |
| Zaratana | This second home boss is an asteroid-like turtle, and you can 1v1 it seven mornings once The Moon is completed. |
| Pyrophina vs Zaratana | Once you smash Zaratana, the next house boss battle (Pyrophina vs. Zaratana) will open up for you around seven in-game days later. |
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All Bosses in Act 3 in Mewgenics
| Chapter | Mini Boss | Final Boss |
|---|---|---|
| The Lab | Alice Chan Hung Draven Franklin Arthur (Special) | Spewer Stacy |
| Ice Age | Frostbiter The Rocksnows | Lord Bunga |
| The Future | Dr. Mangler Zapphauser | Hitler II |
| The Jurassic | Dino Lovers | Dreadnoughtus |
| The End | The Bloat | The Mother |
| The Infinite (Secret) | None | The Creator |
Others from Act 3
| House Boss | Location |
|---|---|
| C-800 | Armed with a shotgun, this terminator cat is tough to handle. It can show up after you wrap up The Future/The End. |
| C-1000 | As with C-800, this is the second home boss, available to 1v1 once The Future/The End is wrapped up. |
| Hitler III | You must solve the Act 3 puzzle before the final home boss can raid your home. |
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2026-02-20 12:06