Once Human: 10 Best Prismverse Specializations

Once Human: 10 Best Prismverse Specializations

Key Takeaways

  • Unique specializations in Once Human‘s Prismverse Scenario suit both PvP and PvE players, not restricted to factions.
  • Hand-picked specializations based on playstyle and game content can enhance optimal base strategies.
  • Different Drone modules offer bonuses for passive farming, support, invisibility, healing, and complementing primary modules.

As a seasoned player in this thrilling universe, I can confidently say that the choice of Genes can significantly shift the tide of battles and enhance your gameplay experience. Each Gene offers unique benefits tailored to different roles within the hive, and it’s crucial to make an informed decision based on your playstyle.


There’s no question that the Prismverse Scenario of Once Human is an intense game mode where players from both PvP (Player vs Player) and PvE (Player vs Environment) have united to engage in faction conflicts. Distinct specializations have been incorporated, and these aren’t confined to factions. As a Rosetta, you can acquire the Mayfly specialization, and conversely, as a Mayfly, you can become a Rosetta.

In some cases, conducting base assaults, adjusting prism deviations, and engaging in large-scale battles might feel overpowering if you lack special advantages. It’s crucial to understand which benefits align with your preferred approach to gameplay and make the right choices accordingly.

For those PvE players venturing into PvP for the first time, here are some tailored specializations we’ve selected to enhance your basic strategies and provide specialized tactics for different scenarios.

10 Elysium Coherence Injection

Staying In The Territory Gives Coherence Points

Once Human: 10 Best Prismverse Specializations
Fragment TypeEffect
Deviant FragmentGrants the double jump ability with the Aero leap effect (The effect is also maintained as long as you have 10 points outside the territory)
Anima FragmentBoosts the attack of allied turrets and traps within the territory by 50 %
MatterlithStamina consumption -30%, Roll speed +30 % and Tactical item +30% within the territory
StarlithIncreases PSI intensity by 1% per stack, but reduces attack by 0.5%. Each shot consumes one coherence point.

If you primarily function as a forager or are part of the protective unit at your primary purification hub, I’d advise you to employ the Elysium Injections. The tactical enhancement this item provides to damage makes it easier to obliterate neighboring bases or camps. These destruction opportunities can be utilized to launch Biomass missiles at your main base for a raid.

If you don’t have the Atomic Snail Deviation, you won’t be able to craft the Aero Leap Whim potion, so it makes sense to use the Deviant Fragment. With extra boosts to turrets and traps, enemies will have difficulty breaching the base’s inner portion.

An enhancement in the strength of PSI intensity particularly boosts the effectiveness of build strategies centered around elements and amplifies the potency of lightning strikes against intruders, causing them more harm.

You need to maintain or accumulate Coherence Points to utilize injection bonuses. Each injection has a different criterion.

9 Primary Module: Focus Module

Passive Farming

Once Human: 10 Best Prismverse Specializations
Drone TypeFocus Module Effect
Gathering DroneThe drone has a chance to extract 10-100 Barreled Crude Oil while mining in the contested areas.

Developing expertise in areas such as Oil Processing can aid you in producing large quantities of Stardust Source for your fellow hive-dwellers and faction members. With an abundance of Stardust sources available, crafting Tungsten AP ammo becomes effortless. To obtain Portable Mixed Fuel, which is essential for this process, you can refine Barreled Crude Oil within the game.

In just three simple steps, you can take control of the Blackfell Oil Fields:

All the drone perks only work when they’re active, which means you have to summon them.

8 Primary Module: Speedy Module

Quality Of Life Combo

Once Human: 10 Best Prismverse Specializations
Drone TypeSpeedy Module Effect
Gathering DroneMax stamina increases by 50, movement speed by 20%, and sprint speed by 30%, with a 200% final hit yield when the player holds a gathering tool.
Territory DroneStamina consumption decreases by 30%, Roll speed, and Tactical Item damage increases by 30% when you’re not in your territory
Explorer DroneIt grants the player the double jump ability with a +15 % movement speed bonus

The Speedy Module streamlines your role selection process. Scavengers can swiftly traverse disputed areas at an accelerated pace, amassing Aluminum, Steel, and Tungsten Ores in just a few minutes. On the other hand, the Tactical Item damage bonus for the primary Assault squads is crucial for breaching walls or attacking enemy bases.

The strike or raid teams can also use the Explorer drone to achieve increased movement speed and jump from cliffs to glide on the top of enemy bases.

7 Primary Module: Support Module

Support Your Team

Once Human: 10 Best Prismverse Specializations
Drone TypeSupport Module Effect
Territory DroneYou’ll recover 5% HP per second in your own territory; if the HP drops below 50%, the player becomes invisible. (Cooldown: 130 seconds)
Firepower DroneHeals a nearby ally with the lowest HP and removes a player’s fallen state if they don’t black out within 10 seconds.
Gathering DroneConverts ores into ingots every 30 seconds
Explorer DroneAfter leaving combat, the player enters an invisible state.

Top-tier support modules are ideal for all drones. In critical combat scenarios, having an invisible drone can help secure decisive one-shot victories using the Territory Drone. Additionally, pairing this with the Firepower Drone’s healing advantage from fellow players enables you to safeguard your base for extended periods without frequent respawns.

Regarding the Gathering drone, turning ores directly into Ingots is quite beneficial as it eliminates the need for charcoal or acid in the process.

To wrap it up, the stealthy nature of the Explorer drone makes it ideal for surveillance operations as it evades detection by adversaries. This allows you to gather intel and share it with command centers or strike force leaders, facilitating strategic planning for a potential large-scale assault on enemy bases.

6 Secondary Module: Healing Module

Complimentary Bonuses

Once Human: 10 Best Prismverse Specializations
CompatibilityAny Drone
Module EffectAutomatically consumes 10 Adhesive, 10 Metal Scraps and 5 Rubber to restore 50% durability to the lowest gear being worn every 10 minutes

The healing module is quite light on your inventory as you can effortlessly gather Adhesives, Metal Scraps, and Rubber from the Silos and overworld. Most PvE players lack the Artisan’s Touch Deviation skill, which means they frequently need to return to their bases to mend their equipment.

It would be wise to equip the Healing module as an additional feature when building drones for the purpose of repairing your equipment.

5 Secondary Module: Invisible Module

Reconnaisance Mode On

Once Human: 10 Best Prismverse Specializations
CompatibilityAny Drone
Module EffectThe drone enters an invisible state by automatically consuming 10 stardust sources for 5 minutes. It then exits the state to attack.

An amazing option for teams defending the territory or participating in raids. The drones are squishy and can be one-shot by enemies. However, enemies will have difficulty shooting down your drones if the model isn’t visible.

The target area is marked, however, the drone has entirely vanished. If you can afford it, I recommend selecting this module with sufficient Stardust resources at your disposal.

A general rule of thumb is to max out your gear and weapons first and then spend Stardust sources.

4 Speed Coherence Injection

Moving Grants Coherence Points

Once Human: 10 Best Prismverse Specializations
Fragment TypeEffect
DeviantVertical gliding speed reduces by 70%, while horizontal gliding speed increases by 50%.
AnimaRecovers 5%HP and sanity per second while driving and gain a shield equal to 60% of Map HP when exiting driving (cooldown 30s)
StarlithGain invisibility for 10s after gliding ends
MatterlithWeapon damage, status damage and damage reduction increase by 20% in a mobile territory or truck.

As an enthusiastic gamer, I’d highly recommend the Speed Coherence Injection for those who prefer a bold and aggressive playstyle, particularly members of the main strike or raid teams. This injection harmonizes exceptionally well with tanky PvP armor builds that deviate from the standard PvE builds, offering less conventional damage reduction.

That gives them ample time to relocate their siege bases and attack the enemies’ defense bases.

3 Nurture Coherence Injection

Gathering Grants Coherence Points

Once Human: 10 Best Prismverse Specializations
Fragment TypeEffect
DeviantMining strike speed +50 with mining last hit yield +100%
AnimaThe yield of logs and ores (Sulfur, Silver, Gold, and Stardust) increased by 30% with +15% movement speed while holding a pickaxe or chainsaw
StarlithConsumes all coherence stacks to increase the final yield hit from logging and mining by 1000% for 5s
MatterlithA chance to obtain 30 barrels of crude oil for allied players within 5 meters in contested areas while mining.

From my perspective, I find that the bonus advantages for Mayflies in the Prismverse situation surpass those of Rosettas, as the increase in resource farming is significantly more substantial with Mayflies.

On most fragments, you’ll earn percentage-based rewards, and during farming runs with allies, there’s a bonus for Barreled Crude Oil that benefits everyone involved.

2 Injection Genes

One Up For Your Injections

Once Human: 10 Best Prismverse Specializations
GeneGene Effect
ProliferationCreates a proliferation zone to increase the acquisition amount of all parts, fabrics, plastic, metal scraps, rubber, adhesive, electronic parts, crystals, and acid by 30% for 10s
ExtremeYou lose stacks after receiving 150% damage to your max HP. When HP is below 50%, your max load is +50. When HP is below 30%, weapon damage and tactical damage are +15%. Finally, you recover 1% of the Max HP for each unused Max load point below 10% HP.
LightningDeals 4,000% PSI intensity lightning damage to a random enemy within 20 meters every 10 seconds after a 3s delay.
BastilleEnter the Bastille state after standing still for 2 seconds. Get +10% damage reduction, +20% Weakspot damage reduction, and marks enemies when hit. (cooldown 10s)

Later in the game, you’ll have the option to select Genes for your injections, amplifying the benefits of those injections even further. While Lightning and Bastille are widely favored, alternatives such as Extreme and Proliferation can aid you in Resources Collection and Territory Protection.

It’s advisable to select the gene that best suits your function within your colony. For those primarily focused on gathering resources and defending the territory, passive genes are suggested. On the other hand, if you’re part of the raiding party, more aggressive genes might be beneficial.

At the time this guide was written, the Proliferation Gene appears to be malfunctioning. It might be corrected in the future.

1 Gene Fabrics

It’s A Must

Once Human: 10 Best Prismverse Specializations
Gene FabricsTop Armor Piece Effect
ProliferationConverts Barreled Crude Oil to Portable Mixed Fuel every 30 seconds in the Coherence state
ExtremeGain invincibility. However, the weapon, status, and tactical item damage drop to 0 for 2s.
LightningDeals a 4000% PSI intensity lightning damage to an attacker after a delay of 3s. (cooldown 30s)
BastilleAutomatically consumes 10 stardust sources per minute to restore 10% durability to a gear piece with the lowest durability

Always use Gene Fabrics in the late game for your gear. The Lightning Gene is a double-edged sword since it targets an attacker, not an opposing faction member.

If you were to injure yourself by throwing a Molotov cocktail, it would cause a bolt of lightning to appear and potentially strike down a teammate who is close to you. As a PvE player, I’m currently equipping one Lightning Gene Fabric for its offensive capabilities along with 5 Bastille Gene fabrics to enhance the durability of my gear.

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2024-10-16 17:10