Summary
- Enter The Gungeon offers diverse synergies, like Old Goldie + Gilded Bullets for increased damage.
- Obtainable combos like Lil’ Bomber + Coin Crown help players gather currency easily in runs.
- Advanced synergy like Metronome + Drum Clip can stack damage on kills, reaching 250% bonus damage.
There’s plenty of incentive to go back to the indie roguelike bullet hell game, “Enter The Gungeon,” developed by Dodgeroll Games. Despite being around for some time, it still offers a wealth of replay value due to multiple updates since its 2016 launch. With hundreds of weapons and items to unlock, numerous bosses to conquer, secrets to uncover, and various modes to explore, this game keeps both newcomers and long-time players engaged.
One captivating aspect of Enter The Gungeon‘s roguelike structure lies in its interconnected item abilities, often referred to as item synergies. As players progress through a run, they collect passive and active items, along with weapons. Combining specific items, weapons, or even item-weapon pairs triggers unique synergies, offering extra benefits beyond the standard effects of each item or weapon.
In this discussion, we’ll be zeroing in on synergies that necessitate two items or one item plus a weapon to function. These, you’ll find, are the most easily attainable during a single playthrough compared to lengthier synergy combinations. The latter can be quite challenging, even for seasoned players, due to their reliance on luck to gather the necessary components. Herein lies our pick of top Synergies in Enter The Gungeon.
10. Old Goldie + Gilded Bullets
Low Health, High Damage

- Combo Effect: Increased damage (Vastly increased damage at low health)
- Combo Name: Ecstasy of Gold
Old Goldie, a formidable shotgun, and its ammunition, the elegantly named Gilded Bullets, create a potent duo. The weapon experiences a 25% boost in damage when these bullets are carried. However, their true might lies not just in this visible enhancement, but also in Old Goldie’s secret attributes as well.
Losing health points makes my weapons pack a stronger punch. When my weapon is at its peak enhancement and factoring in bullet impact, I can dish out a whopping 220 damage with just one shot from the shotgun โ perfect for swiftly cleaning up an entire room!
9. Lil’ Bomber + Coin Crown
Golden Bombs

- Combo Effect: Bombs become gold and enemies drop shells when hit
- Combo Name: King Bomber
King Bomber is an excellent choice for players aiming to accumulate a substantial amount of in-game currency during their playthrough. What makes it even more appealing is its accessibility, as the necessary components are frequently discovered early on in a player’s run. This is due to several possible combinations that can trigger this effect.
In every instance, the Little Bombardier weapon is essential; however, the reward becomes active with Goldened Bullets and the Crown of Firearms, plus the Coin Crown too. (This version tries to maintain the original’s structure while using simpler language.)
8. Metronome + Drum Clip
Combat Rhythm

- Combo Effect: Metronome gains 4% damage per kill, and caps at 250% damage
- Combo Name: Keeping the Beat
For proficient “Enter The Gungeon” gamers, there are scarcely any synergies as potent as maintaining the rhythm of Keeping the Beat. This metronome item offers a cumulative damage boost until the player takes a hit or switches guns, and the drum clip amplifies the bonus and raises its maximum limit. Once a player achieves a 75-kill streak, their damage output escalates by 250%. However, this is contingent on avoiding all hits throughout the gameplay.
7. Chest Teleporter + Teleporter Prototype
Potent Prototype

- Combo Effect: Kill all enemies when teleporting into a room
- Combo Name: Telefrag
Almost feels as if this game combo gives an unfair advantage: The teleporter gadget is perfect for adventurers seeking quick progress in the Gungeon. However, it might lead to tricky situations when players instantly appear amidst a challenging horde of foes.
With this combination, problems are quickly resolved because enemies are immediately eliminated when players enter a battle chamber through teleportation. Additionally, the cool-down time for the teleporter reduces if players find themselves in a hidden room with this particular interaction.
6. Gunsoul + Old Knight’s Flask
Somewhat Souls-Like

- Combo Effect: Creates respawn bonfires and decreases dodge roll cooldown
- Combo Name: Praise the Gun
As a dedicated gamer immersed in the world of Dark Souls, I can’t help but appreciate a subtle nod to my favorite series in an indie roguelike game. Not only does this reference enrich the gaming experience, but it offers a tangible advantage too. When I possess both the Gunsoul and the Old Knight’s Flask, those familiar bonfires start popping up at shops and elevators! Instead of respawning at the beginning of a floor, I can now revive myself at these convenient spots. To sweeten the deal, dodge rolls also have a reduced cooldown, making gameplay that much smoother.
5. Gunknight Greaves + Ballistic Boots
Revenge Time

- Combo Effect: Stop time when hit
- Combo Name: Knight Time
If you’re looking for some wiggle room when getting attacked in the game, the Knight Time synergy could be a powerful combination for you. When equipped with both the Gunknight Greaves and Ballistic Boots, a hit will momentarily pause time. Although the paused state is temporary, it offers you a few precious seconds to readjust your position or eliminate pesky enemies more effectively.
4. Lowercase r + Explosive Rounds
Uppercase R

- Combo Effect: Rounds explode and firing patterns spell new words
- Combo Name: Reactive
Among all weapons, the lowercase ‘r’ boasts a unique blend of interactions more so than any other. Fitted with explosive ammunition, its own bullets transform into explosives. What’s fascinating is that when fired, these bullets arrange themselves to form words such as ROCKET and KABOOM. This versatility extends to various types of ammo and additional items, with each alteration affecting the ‘r’s characteristics and shooting style differently.
3. Gungeon Ant + Crown Of Guns
Queen Gungeon Ant

- Combo Effect: Gungeon Ant becomes an Ant Queen and fires rocket ants
- Combo Name: Great Queen Ant
Using the Great Queen Ant synergy with Gungeon Ant significantly upgrades a mediocre weapon to a powerful clearing tool. This synergy can be triggered in several ways: by obtaining the Crown of Guns or Heck Blaster weapons together with the Gungeon Ant, or by picking up the Ring of Fire Resistance, Gilded Bullets, or the Coin Crown items. Once activated, the Ant transforms into the Ant Queen, launching explosive rocket ants for increased damage.
The Great Queen Ant synergy makes a weak weapon strong by turning it into a clearing machine in Gungeon. You can activate this synergy in different ways such as having the Crown of Guns or Heck Blaster weapons along with the Gungeon Ant, or by getting Ring of Fire Resistance, Gilded Bullets, or Coin Crown items. Once activated, the Ant becomes the Queen Ant, shooting explosive rocket ants for more damage.
2. AKEY-47 + Shelleton Key
Trade Utility For Damage

- Combo Effect: Increased damage and infinite ammo, AKEY-47 no longer opens locks
- Combo Name: AKEY Breakey
In this setup, the AKEY-47 loses its key functionality, yet it significantly enhances its damage output and provides unlimited ammunition. Essentially, each shot deals almost double the original damage (an extra 10 per shot), and the infinite ammo makes it a formidable weapon due to this powerful ability. Consequently, the AKEY-47 transforms from a reliable weapon with useful features into a game-changing gun, ideal for solo or team play.
1. Betrayer’s Shield + Lies
Infinite Damage

- Combo Effect: Increased fire rate, clip size, and infinite ammo, can no longer reveal secret rooms
- Combo Name: Betrayer’s Lies
Among all combinations in the game, the harmony between the Betrayer’s Shield weapon and the Lies passive item could potentially offer players the most effective assistance for quickly overcoming rooms and vanquishing bosses.
By gripping deceit, the user’s Defensive Barrier significantly upgrades. It now has an endless supply of ammunition, larger magazine capacities, and an exceptionally rapid rate of fire, spewing bullets at astonishing speeds. The unique feature of these weapons, which creates a barrier that thwarts enemy gunfire during reloading, makes this one of the most powerful weapons in the game when combined effectively.
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2025-03-11 19:16