The Binding Of Isaac Rebirth: Best Unlocks

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Summary

  • The D6 allows players to re-roll items, unlocking it by defeating boss Isaac with ???
  • Azazel, unlocked by 3 deals with the devil, offers powerful Brimstone tears and flight.
  • Unlock Mom’s Knife by beating Satan with Isaac for a game-changing, penetrating knife.

In the game titled “The Binding of Isaac: Rebirth“, players embark on a perilous adventure with Isaac, navigating through his mother’s basement. As they conquer floors and overcome challenges, they unlock an array of achievements, items, and characters that bring diverse play styles. These unlockables present different advantages, but some are evidently more advantageous than others.

As a seasoned gamer, I can’t stress enough the impact of knowing which unlockables to prioritize. Each one comes with its own set of unique challenges that even the sharpest minds might find tough. With an abundance of options at our disposal, it’s easy to feel overwhelmed when deciding where to start. However, these are some game-changing unlocks that no player should pass up!

7. The D6

Re-roll At Will

  • Action: re-rolls items in a room
  • Unlock: defeat boss Isaac with ???

When players initially begin with Isaac, they might observe that certain items within rooms don’t perfectly suit their preferences or requirements. Regrettably, at the outset, they are confined to the items presented. However, upon unlocking the D6, they acquire the ability to reroll the items in a room, excluding pickups and trinkets. This encompasses chest items, shop items, devil deals, and numerous other possibilities.

In simple terms, you can unlock the D6 by overcoming the boss Isaac when he’s in the Cathedral while playing as Blue Baby. After it’s unlocked, each time you start a game with Isaac, he’ll have the D6 already activated. This unique item significantly boosts Isaac’s power compared to his regular form.

6. Azazel

Powerful And Dependable

  • Action: shoots Brimstone tears and has flight
  • Unlock: take three deals with the devil in one run

In this game, Azazel is among the strongest characters you can play as, yet he isn’t immediately accessible; you need to unlock him first. His standout features are his Brimstone tears and flight capability, making him incredibly versatile. He begins with three black health points, but can also gather red health points throughout your journey.

Players can acquire Azazel faster by striking three pacts with the devil during a single playthrough. It’s beneficial for them to strive to get him early, since this character grants access to additional fantastic items, making gameplay much smoother.

5. Mom’s Knife

Replacing Tears With A Knife

  • Action: replaces Isaac’s tears with a penetrating knife
  • Unlock: beat Satan with Isaac

Unlocking Mom’s Knife could significantly alter the gameplay for Isaac. Upon activation, it transforms his tears into a lethal blade that inflicts piercing damage. Moreover, this item serves as a versatile melee weapon, swiftly eliminating weaker opponents with a fatal blow.

To acquire this item, players must embark on a journey that leads them to confront Satan. Upon successfully defeating Satan, they can utilize the character Isaac for the task. Overcoming Satan with various characters will grant access to distinct items.

4. Aprils Fool

Magdalene Gets A Speed Pill

  • Action: grants Magdalene a Speed Pill
  • Unlock: Complete Challenge #32

Magdalene is a well-rounded character overall, but she could use some improvement in the Speed department. To assist her with that, players can take on Challenge #32: April’s Fool. During this challenge, Isaac doesn’t receive any special items, and all floor bosses are replaced with The Bloat instead.

As a fan, I’m diving headfirst into the battle against Mom’s Heart, only to discover it has been transformed into The Bloat. Victory in this fight grants me a Speed Pill, but be warned – any item I pick up during this challenge undergoes an unexpected transformation. This entire challenge seems deliberately designed to push me to my limits, making every step a test of skill and patience.

3. The Relic

Drops Soul Hearts

  • Action: follows Isaac and drops a soul heart
  • Unlock: defeat boss Isaac as Magdalene

Once The Relic is activated, it behaves much like a pet accompanying Isaac. Yet, this isn’t your typical companion – every fifth or sixth room it enters will yield a Soul Heart. With the addition of specific other items, the Soul Heart generation interval increases to once every seven rooms.

To unlock The Relic, players must first defeat the boss Isaac using Magdalene. Regardless of a player’s ability to dodge damage, this unlockable item can significantly boost their chances of surviving the entire run.

2. Blank Card

Mimic Active Cards

  • Action: copies the equipped Card or Rune’s effect
  • Unlock: defeat boss Isaac as Eden

When players acquire the “Non-Consumable Card”, they can utilize their in-game items without reducing their quantity. This handy card simulates the effects of compatible items without depleting them. However, if it’s mistakenly used with an inappropriate item or no item at all, it will lose its charge without producing any result.

If gamers manage to overcome the boss Isaac while holding Eden, they’ll gain access to The Blank Card. The duration until it can be reused will change based on specific conditions and items employed. However, conserving non-renewable items initially can significantly impact a player’s gameplay experience.

1. Satanic Bible

Gain A Black Heart

  • Action: gives a single black heart
  • Unlock: defeat boss Isaac as Azazel

To open the mysteries of The Satanic Bible in the game, you need to employ Azazel as your character for the run. Since Azazel is quite simple to handle, overcoming Isaac using him should not be excessively difficult. What makes it even more enjoyable is the impact of The Satanic Bible.

As a gamer, I’ve got this item here, it’s called the Satanic Bible. Activating it gives me one black heart. That’s like striking a bargain with Old Nick, a move that usually spells doom for most. But fear not, because instead of meeting my demise, activating this bad boy ensures I survive the deal and keep on playing my run.

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2025-01-05 02:04