The First Descendant: Best Python Build

As a seasoned player of The First Descendant, I must say that the Python weapon has become my go-to ultimate weapon in various situations. Whether it’s farming for resources, battling Void Intercept bosses, or venturing into hard difficulty regions, this versatile weapon never disappoints.


As a gamer, I’ve come to appreciate the Python as my go-to ultimate weapon in The First Descendant. This bad boy really shines due to its knack for debilitating enemy defense and toxic resistance, making it a lifesaver when tackling beefy targets like Colossi. However, there’s a catch – its unique ability activates only when I manage to hit the enemy’s weak points. That means it’s more effective in one-on-one skirmishes than against hordes of Vulguses.

If you aim to fully utilize the potential of this extraordinary weapon, devote considerable care to its details, particularly when selecting the modules you attach to it. To assist you in maximizing its damage output and gaining optimal value, I’ve outlined a comprehensive guide on how to construct the Python within “The First Descendant”.

What is Python in The First Descendant?

In “The First Descendant,” the Python is an exceptional tool, resembling a super machine-gun, equipped with a distinct ability known as the Python Instinct. When you strike an enemy’s vulnerable spot, the Prey status activates, lowering the target’s Defense and Toxin Resistance by 10%. This feature makes the Python highly effective against Colossi and enemies with high resistance. However, it shines in single-target combat but may face challenges in managing crowds because of its Weak Point reliance. Below are the base stats for the Python weapon to give you a clearer understanding of its capabilities:

Stat Value
Firearm ATK 21
Fire Rate 923
Rounds per Magazine 30
Reload Time 1.5 seconds
Crit Rate 5%
Crit Damage 1.3x
Status Chance 3.45%
Weak Point Damage 2x

For Descendants, Python’s debuff is beneficial overall, but it significantly amplifies the poison damage for characters with a focus on poison, such as Freyna. Since she can exploit the reduced Toxic Resistance, her poison attacks become even more potent. Similarly, Ajax, with his robust build and high defense statistics, can also make use of this debuff due to its adaptability.

Best Early Game Python Build

Module Effect
Have Aiming Increases Weak Point Damage by 10%, though it slightly reduces accuracy.
Action and Reaction Boosts a flat DPS increase from Firearm ATK by 15% and increases recoil by 5%, overall enhancing the damage output.
Rifling Reinforcement Adds 12% Explosive ATK, making it a solid choice for increasing overall effectiveness.
Weak Point Sight Boosts Weak Point Damage by an additional 9%, helping you maximize the weapon’s DPS against single targets.

In the initial stages of the game, Python is primarily utilized to inflict high damage on single targets like Vulguses, particularly by focusing on their vulnerable spots and making use of the ‘Prey’ debuff against bosses. The key components for the early-game setup are ‘Firearm Attack’ and ‘Weak Point Damage’.

These modules are designed to enhance Python’s ability to deal more damage to its vulnerabilities, making it exceptionally powerful against bosses and Colossi. As a result, you can expect an approximately 20% boost in your weak point damage, which brings the damage figures close to about 2.5 times the base damage.

Best Late Game Python Build

Modules Effect
Poison Priority Increases Toxic ATK by 13% and reduces reload time by 8%, making it ideal against electric-type Vulguses and even Colossi.
Fixed Shot Reduces recoil by 8% and increases Weak Point damage by 2%, further bolstering the weakpoint damage and also providing stability.
Mental Focus Reduces fire rate by 10%, but provides increased Firearm ATK. It helps balance Python’s fast-firing with substantial damage boosts.
Weak Point Aiming Increases accuracy and weak point damage by 8% and 2%, respectively.
Toxic Enhancement Adds Toxic ATK equal to 8% of Firearm ATK, increasing Python’s synergy with Toxic builds.

As the game progresses and I face off against formidable Colossus foes, the Python truly shines. To fully harness its might, I need to tailor my build towards amplifying its already potent Weak Point damage and fortifying Toxic resistance debuffs. This transformation turns the Python into a relentless DPS beast, capable of tearing through even the toughest boss and elite battles.

Using this construction, Python transforms into a potent, accurate weapon due to its Fixed Shot and Mental Focus abilities. These traits make it effective against formidable Colossi, particularly when wielded by characters like Freyna, who can maximize the increased Toxic damage.

Best Python Build for Farming

Modules Effect
Have Aiming Boosts Weak Point Damage, boosting DPS to clear mobs quicker.
Action and Reaction A flat 15% boost to Firearm ATK increases DPS even more.
Fire Rate UP Increasing the fire rate by 6% is essential for farming, as it increases the efficiency of clearing mobs significantly.
Weak Point Sight Increases the Weak Point Damage output even more to help deal with occasional elite Vulguses.

In the game “The First Descendant”, it’s crucial to have a high fire rate and exceptionally high damage per second (DPS) when farming. Python is often a suitable pick for gathering valuable resources, particularly in areas where electric-type adversaries like Hagios or Kingston are dominant. With this build, you can effortlessly farm resources in various regions, even on challenging difficulty levels.

If you find yourself stuck in any areas on the Hard setting, enhancing your module levels should help you overcome those challenges eventually.

Best Python Build for Void Intercept Battles

Modules Effect
Poison Priority Increases Toxic ATK by 13% and reduces reload time by 8%, making it ideal against electric-type Colossi.
Fixed Shot Reduces recoil by 8% and increases Weak Point damage by 2%, increasing the weakpoint damage and providing stability.
Mental Focus Reduces fire rate by 10%, but provides increased Firearm ATK, which means more DPS.
Weak Point Aiming Increases accuracy and weak point damage by 8% and 2%, respectively.
Rifling Reinforcement Explosive ATK boost adds a little extra punch espeically if you don’t have type-advantage.

In Void Intercept battles, powerful weapons are a must, and Python stands out as one of the rare Ultimate Weapons that excels in this game mode. Given its ability to apply debuffs on defense and Toxic resistance, it is exceptionally potent against solo bosses.

To effectively damage the colossi, concentrate on striking their weak spots regularly. This weapon build makes Python exceptionally effective against bosses like Executioner, Devourer, and the Hanged Man, as it takes advantage of an extra type advantage in those particular battles.

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2024-11-17 23:05